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Acting as second messengers in the insulin cascade, IPGs facilitate glucose uptake, glycogen synthesis, and lipid metabolism through the activation of key enzymes such as pyruvate dehydrogenase and glycogen synthase (135)

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The data in a and ce were analyzed using the Kruskal-Wallis test, followed by Dunns post-hoc test

Rondinone CM, Valdecantos P, Rada P, Valverde AM, Ghosh S (2024) Novel unimolecular tetra-agonist peptides targeting GLP-1, GIP, amylin, and calcitonin receptors with enhanced metabolic benefits in animal models of obesity

Cells at passage 3 were used for downstream experiments

Wei H, et al