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Indian J Physiol Pharmacol 54(1):2131 Rodrguez-Muoz M, Snchez-Blzquez P, Vicente-Snchez A, Berrocoso E, Garzn JJN (2012) The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control

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The same body of research also found that higher doses of GHK-Cu can produce skin irritation, and that copper in general is highly toxic, which is why formulation and concentration matter considerably in any experimental design involving this compound