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FDA approval was based on the SOUL cardiovascular outcomes trial (CVOT) that demonstrated a 14% relative reduction in risk of MACE in patients treated with Rybelsus 14 mg orally once daily for approximately 5 years compared to those who received placebo

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doi: 10.1016/j.brainres.2016.04.060, PMID: [DOI] [PubMed] [Google Scholar] 88

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GLP-1 RAs have also been suggested to be nephroprotective [10], even though conflicting data on renal sodium and water handling have been reported [10,11,12]

[Clinical efficacy of intravenous L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension]