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+ channel activation The Na + channel is activated by the physical impact on the brain tissue in TBI which leads to initiation of action potential and loss of membrane permeability culminating in necrosis and free radical generation (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury

The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates

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