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[DOI] [PubMed] [Google Scholar] Nystrm T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrn B, Sjholm A

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Additional information The EMBO Journal (2019) 38: e101552 Rights and permissions This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited

Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification

Tau, which is normally a microtubule-stabilizing protein, becomes pathogenic after being hyperphosphorylated, thereby compromising neuronal transport systems

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