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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27
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Additionally, mitochondrial energy metabolism and inflammatory cytokines pathways were unaffected or downregulated, and no changes in functional readouts like hand grip strength were observed
They have an inverse relationship with correlation coefficients between -0.95 and -0.99
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