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Neurology 51 , 15621566 (1998)

10.1371/journal.pone.0057226 35 Mller-RverS.HandjiskiB.van der VeenC.EichmllerS.FoitzikK.McKayI

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The result slower skin cell turnover, reduced collagen synthesis, weaker repair response to sun damage and environmental stress is what most people notice as the first signs of aging