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Trials need to include a wider range of patients, for example more work is needed in looking at treatment in both acute and chronic PD

PMID: 41865607 J Chromatogr B Analyt Technol Biomed Life Sci Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS

It should be taken on an empty stomach, typically 30-60 minutes before eating, separated from other medications and supplements by at least 4 hours (for calcium, iron, and similar minerals)

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References Rossino G, Marchese E, Galli G, et al