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26 Furthermore, a single-center, parallel-group, randomized, placebo-controlled study, which included 101 patients with biopsy-proven NASH and prediabetes or DM2 (NCT00994682), showed significant improvement of nonalcoholic fatty liver disease activity score in 58% of the patients in the pioglitazone group (vs

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The fact that multiple independent review sites rate it in the 3-3.5 range out of 5 places it squarely in the "adequate" category, not the "excellent" one

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Grove and Kligman's research suggested the decline in epidermal renewal may remain relatively constant in younger years and then drop sharply after age 50 (PMID: 6827031)