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Originally, the concept holds the epithelium/endothelium protection achieved against direct injury made by noxious agents by contact in the stomach, as direct cell protection, to be translated unlimitedly to the entire body [35,36,37,38,39,40,41,42]

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Washing skin thoroughly within 10 to 15 minutes of contact is the single most effective way to shorten the reaction

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Importantly, a connection between ephrins and VEGF signalling has also been shown