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As depicted in Figure 4, unscavenged superoxide inactivates aconitase by displacing Fe +2 from the Fe-S cluster, which then promotes the formation of the damaging hydroxyl radical via reaction with H 2 O 2 and Fenton chemistry

Urakaze, M., Kobashi, C., Satou, Y., Shigeta, K., Toshima, M., Takagi, M., Takahashi, J., & Nishida, H

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96 These studies have shown that AATs are potential targets for tumor metabolic reprogramming