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Hyperactivity of entorhinal cortical and hippocampal circuits are also thought to underlie neurodegenerative disorders, such as AD and mild cognitive impairment (MCI) (268272)

doi:10.1001/jamainternmed.2013.2720 80

Conversely, it is easy to have a deficiency, especially with restrictive diets

As mentioned above, TFCs express toll-like receptors, which induce the activation of the innate immune system by responding to the PAMPs and damage-associated molecular patterns (DAMPs) on the surface of microorganisms, making lymphocytes product multiple proinflammatory cytokines, such as IL-1, IL-18, IFN-, and TNF- [186]

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