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argued that Lurcher mice have no difficulties in swimming, as their swimming speed is similar to that of WT mice [119], concluding that the impairment in the water T-maze and MWM tests are not associated with an effect of motor disturbances

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While immunosuppressive factors such as CCL2, CXCL12, IL-4, and IL-10 sustain an immune-excluded TME, pro-inflammatory mediators like IFN-, TNF-, and CXCL10 counteract these effects by promoting immune cell infiltration and tumor suppression

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