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To our knowledge, this is the first Mendelian randomization study to assess the associations between GLP-1RAs and these psychiatric conditions

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GRMTree identified three distinct subgroups exhibiting DIF on the MOS-SS emotional domain, defined by age and sex, indicating that these covariates were associated with DIF in patients responses

Adverse events The most frequent adverse events in patients included in the analysis were mild or moderate and gastrointestinal (GI) in nature

Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice

However, direct head-to-head trials between these two specific molecules are limited, meaning researchers must look at their respective large-scale trial programs