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For injectable routes, beyond localized reactions like pain or swelling at the injection site, observing for systemic effects becomes paramount

Likewise, the activation of TRPV1, which suppresses the ferroptosis pathway in chondrocytes, has been shown to slow the development of OA [111,112]

Cai L, Jin X, Zhang J, Li L, Zhao J (2020) Metformin suppresses Nrf2-mediated chemoresistance in hepatocellular carcinoma cells by increasing glycolysis

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Sci Rep 12 , 4287 (2022)

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