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Regions with secondary structures typically exhibit higher hetNOE values ( 0.6)

A value of 100% indicates no drug transport into the brain across the BBB (AUC(brain, IV) = 0) or no drug absorption into the systemic circulation after intranasal administration (AUC(blood, IN) = 0)

A 12-week Phase IIa trial involving 300 participants showed modest reductions in weight (2.6 kg versus 0.8 kg for placebo)

2008 Dec;79(12):1106-11

Most people experience soreness for up to two weeks or more after their surgery, and other minor complications might be a poor appearance of a scar or less-than-desired results

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