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During the main prospective, placebo-controlled trial of liraglutide, 18 gastrointestinal side effects, gallbladder disease, and injection site reactions were reported, though these rarely resulted in permanent discontinuation of the drug (less than 4%)

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We initially quantified mRNA expression levels of H1R, H2R, and H4R by real-time reverse transcriptionPCR in banked clinical samples from newly diagnosed UC patients to determine whether any changes occurred in the histamine receptors compared with non-UC control participants undergoing routine surveillance colonoscopy