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Optionally, a controlled-release formulation includes otoprotective agents, such as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that may arise from the use of specific therapeutic agents or excipients, diluents, or carriers

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Visceral adipose tissue (VAT) is the fat stored deep within the abdominal cavity, wrapped around the liver, intestines, kidneys, and other vital organs