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GLP-1 therapy for eating disorders may also reduce the severity of related metabolic conditions like prediabetes or type 2 diabetes

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120 It has not been established if GIP actives PDX-1 similarly to GLP-1, but the current consensus in the literature is that GIP and GLP-1 activate both similar pathways and different pathways to promote their anti-apoptotic and proliferative effects

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[11] Concurrent administration of any nitrate or NO-donor is absolutely contraindicated because synergistic increases in cGMP can provoke life-threatening hypotension