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In the ATTAIN-1 study, gastrointestinal side effects were generally mild or moderate (2)

Skeletal muscle hypertrophy, which raises the mass of tissue insulin-sensitive in terms of glucose storage and utilization, may be partly responsible for the positive impact of resistance exercise on glucose metabolism outcomes

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Gradual dose reductionif medically appropriatemay smooth the transition compared to abrupt cessation, though this requires individual clinical guidance