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Lack of Clinical Evidence Critical gaps in knowledge: Zero randomized controlled trials on microdosing GLP-1 agonists No long-term safety data for alternative dosing regimens Unknown effects on cardiovascular outcomes Potential for reduced efficacy not captured in models 2

The Journal of pediatrics 2016

Think of it as addressing both the why and the how of perimenopause weight gain

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In the pancreas, this binding stimulates glucose-dependent insulin secretion from beta cells while suppressing inappropriate glucagon release from alpha cells