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doi: 10.1016/0165-6147(86)90420-7

During corticosteroid therapy may occur psychological disorders such as: euphoria, insomnia, mood swings, depression or personality disorders and even severe depression or psychosis

When combined, they support improved recovery, body composition, sleep quality, and healthy aging

It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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Res ., doi:10.1024/0300-9831/a000724