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That dissociation is the strongest practical argument for treating cerebrospinal fluid and plasma markers in these trials as exploratory readouts of target engagement rather than as stand-ins for benefit

The activated macrophages can also be linked to the expression of iNOS and Cox-2, resulting in excessive production of nitric oxide (NO) and prostaglandins (PG), respectively, which is potentially linked to further cell membrane damage and inflammation 65

Mark Fendrick.

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As a pharmacist, I've spent my career watching healthcare focus on treating disease after it appears