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[16] DrugPatentWatch

Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

Hydrolytically sensitive peptides such as Sermorelin and AOD-9604 degrade faster and should be used within 23 weeks, while stabilized analogs like Semaglutide and Tirzepatide can retain potency for 46 weeks

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Clinical trials show approximately 25 to 39% of weight lost on semaglutide comes from lean body mass, but much of that is liver volume reduction and body water, not skeletal muscle