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How to Follow a 4:3 Fasting Plan Safely in the UK Schedule fasting days non-consecutively, prioritise high-protein and high-fibre foods within the calorie allowance, stay well hydrated, and align non-fasting days with the NHS Eatwell Guide to avoid negating the calorie deficit

The mechanism is straightforward: GLP-1 RAs enhance glucose-dependent insulin secretion, and stacking that on top of glucose-independent insulin release from exogenous insulin or sulfonylureas removes the glucose-dependent safety brake

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