Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6
This is why suppliers who charge more and provide verifiable Janoshik testing are often actually delivering better value per dollar than suppliers offering deeply discounted product with unverifiable or fabricated testing
P., & Blair, E
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131 Royal jelly has demonstrated anti-inflammatory, free radical-quenching, antimicrobial, and immune-modulating effects, and may promote cardiovascular, metabolic, and neurological health
One early hypothesis was that chronic morphine treatment enhances endocytosis, but more recent data indicates that the extent of endocytosis is not affected, at least in locus coeruleus (Quillinan et al., 2011)