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To date, observational studies investigating the cardiovascular effectiveness of the combination have either been underpowered or had important methodological limitations, such as immortal time bias.1215181920 Importantly, none compared the combination with either drug class alone or investigated serious renal events, which are clinically relevant outcomes in this patient population.1215181920 The primary objective of this study was to determine whether the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors is associated with a decreased risk of two co-primary outcomes, major adverse cardiovascular events and serious renal events, compared with the use of either drug class alone among patients with type 2 diabetes

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Table 3 Group differences GSH and peripheral blood markers

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Finally, the cells were resuspended in 500 l of PBS and passed through a 70-m nylon mesh filter for analysis via a Cytoflex LX cell analyzer (Beckman, Miami, FL, USA) through CytExpert software

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They were all American, one from Harvard Medical School

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