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Creatine is best taken consistently at the same time each day pre- or post-workout both show similar effectiveness since its benefits are largely cumulative and depend on maintaining elevated muscle creatine stores

249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions

Toxicology Mechanisms and Methods, 25 (8), 596603

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2024 Jun 11;12