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Such a chain of reactive aldehyde accumulation due to decreased detoxification capability is considered to cause aldehyde storm, a vicious cycle of systemic exposure to reactive aldehydes in the Aldh2*2 KI mice

McKee et al., 2009b

Acknowledgements The infrastructure for the NESDA study ( is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10-000-1002) and financial contributions by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Leiden University Medical Center, Leiden University, GGZ Rivierduinen, University Medical Center Groningen, University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum)

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