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Individuals with Wilson's disease, known metal allergies, or those who are pregnant or breastfeeding should consult a GP or pharmacist before use

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The C-domain loops in IGF2 and insulin are shorter and thus cannot reach the CRD, which explains why the CRD of IGF1R is only important for IGF1 binding, but not for IGF2 or insulin binding 24

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Despite the availability of pharmacological treatments, these interventions fail to prevent disease progression due to their limited ability to penetrate the blood-brain barrier (BBB) and systemic side effects