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This usually happens when the dosage is higher than what the body needs or when supplementation is started suddenly

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Kevin J Lenton, Alain T San, Hlne Therriault, Andr M Cantin, Hlne Payette, J Richard Wagner - Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency - Am J Clin Nutr - 2003 Jan

The 0.8:1 glucose-to-fructose ratio hits both carbohydrate absorption pathways at once glucose through one intestinal channel, fructose through a separate route so your muscles get more usable fuel faster without the backup that causes stomach rebellion around kilometer 30