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We found that the young brain model consumes approximately 2 billion ATP molecules per second per NGV unit (where one unit is one neuron, one astrocyte, and their associated extracellular matrix and capillaries) with 8 Hz firing, while the aged brain model consumes around 1.8 billion molecules per second per unit, which aligns well with literature estimates ( Presentation 1: Supplementary Figure S2 )

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