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Under-eating is one of the biggest hidden causes of GLP-1 fatigue

It can act on enterocytes and underlying tissue directly from the luminal side

2014: the FDA approved liraglutide 3.0 mg (Saxenda) for chronic weight management the first GLP-1 drug with an obesity indication

For liver health, GLP-1 medications improve hepatic fat accumulation and liver enzyme levels, showing promise for non-alcoholic fatty liver disease treatment ^40

Injection of the melanocortin receptor agonist Melanotan 2 (MT2) into the VMH also increased glucose uptake in these tissues, indicating that both leptin and MT2 operate through MCRs to modulate glucose metabolism