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Advanced Biomedical Research

FIGURE 1 FIGURE 2 Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine

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In murine macrophages, apigenin treatment (100 M) inhibited NO production, expression of cytokines IL-1, IL-6, COX-2 and iNOS, and MAPK signaling molecules, including ERK and JNK in a noncytotoxic manner [135]