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If metformin is contraindicated or not tolerated, offer an SGLT-2 inhibitor and consider adding either: a GLP-1 receptor agonist for its cardiovascular, renal and glycaemic benefits or tirzepatide for its glycaemic benefits (5) Adults living with obesity If considering medicines primarily for weight management, see information about medicines for overweight and obesity in NICE's guideline on overweight and obesity management

The study was co-led by Markus Stoffel, MD, PhD, of ETH Zurich

doi: 10.1177/0748730407311254 19 ArutjunyanVAilamazyanE

olak, E., Kozi, D., Jovi, J., Risti, G., & Kovaevi, L