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The nine dinucleotide loci (CpG1, CpG2, CpG3, CpG4, CpG5, CpG6, CpG7, CpG8, CpG9) in the GSTA4 promoter region (Chr6:52,977,953-52,995,284, GRCh38/hg38) were selected for DNA methylation pyrosequencing (Figure 1)

100% of participants on the 8 mg and 12 mg doses in Phase 2 achieved at least 5% weight loss

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