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doi: 10.2310/JIM.0b013e31822a29f5 14

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A 1mg intranasal dose could theoretically match or exceed the brain exposure of a 3mg oral dose, though nasal administration introduces variability based on mucosal absorption and nasal cavity drainage

An early arousing response was also observed before the later sleep-promoting period

If the focus is on improving sleep, the timing of the dosage may align with the bodys natural sleep cycle

They also highlighted certain concerns about patient access if the proposal to package payment for CPT code 97008 were to be finalized, noting that packaging this service would create financial barriers for Medicare beneficiaries and limit hospitals' ability to offer this treatment