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(2000) G-protein coupling of mu-opioid receptors (OP3): elevated basal signalling activity

Current research doesn't provide clear superiority for either approach, and individual preference and logistical convenience should guide timing decisions

The ratio of target-receptor agonism can be manipulated to maximise efficacy whilst optimising adverse effects [31]

In the citation, Michalik compares her work with Furdziks: This part of our work is contained in Section 4

Genetic factors affecting receptor expression or downstream signaling may limit effectiveness

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