As a fluorinated analog of cytosine, it enters fungal cells and is converted intracellularly to 5-fluorouracil (5-FU), which inhibits DNA and RNA synthesis, thereby exerting antifungal effects (Lee et al., 2021)
For instance, erastin and RSL3 selectively affects the glutathione antioxidant system, which leads to increase lipid peroxidation and causes the death of cancer cells [29, 87]
Furthermore, ApoE / mice treated with GB significantly inhibited the mRNA level and protein expression of FMO3, and then decreased the concentration of TMA and TMAO, thus slowing down the progression of atherosclerosis
Eliasson, A.-M
More friendly routes of administration, e.g., oral forms, are also expected to be examined
Oral KPV leans on the PepT1 pathway, which is why it is favored for gut-focused research