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Diabetes Care 42:11471154

Kuera, O

Comparative effectiveness of cardiovascular, renal and safety outcomes of second-line antidiabetic drugs use in people with type 2 diabetes: A systematic review and network meta-analysis of randomised controlled trials

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In an age-stratified meta-analysis of ELIXA, LEADER, SUSTAIN-6, EXSCEL, REWIND and PIONEER-6, the HR on MACE was 0.89 (95% CI 0.761.03) in those under 65 years of age and 0.86 (95% CI 0.800.92) in those aged 65 years or older ( p interaction = 0.73), 0.92 (95% CI 0.850.99) in those under 75 years and 0.75 (95% CI 0.610.92) in those 75 years or older ( p interaction = 0.07), indicating that the efficacy of GLP-1RA for MACE is consistent in older patients [8]