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Typically, trials are designed to detect the most serious or common adverse effects

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Yeasir Karim, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka-1212, Bangladesh, for his cordial support

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To estimate the effects of pauses in these drugs, we calculated the cumulative dose (total number of DDDs) for each drug between the last prescription redeemed prior to or at index date until end of follow-up for each individual