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135 , e194751 (2025)

Key areas of interest include: Cell proliferation and differentiation in multiple tissue types Muscle biology , including satellite cell behavior and myostatin-related pathways Metabolic signaling , particularly IGF-1R and insulin receptor cross-talk Tissue maintenance and repair models in long-term aging and glucocorticoid-exposure paradigms By offering a prolonged IGF-1like signal, IGF-1 LR3 enables researchers to investigate sustained pathway activation and long-term cellular responses in a more controlled way than with short-lived native IGF-1

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In healthy cells, p53 activation can initiate DNA repair or apoptosis depending on damage severity

Brown and beige fat: Physiological roles beyond heat generation