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Indeed, the European multicenter study coordinated by Graham reports that, whereas basal hyperhomocysteinemia only shows an additive effect with hypercholesterolemia, it has a synergistic effect with both hypertension and smoking on the incidence of atherosclerotic vascular disease (Graham et al, 1997)
This is a normal and expected response, not a side effect to be concerned about
China Patent Application CN105685226 (A) Yin H, Ma Y, Deng Y, Xu Z, Liu J, Zhao J, Dong J, Yu J, Chang Z (2016) Genome shuffling of Saccharomyces cerevisiae for enhanced glutathione yield and relative gene expression analysis using fluorescent quantitation reverse transcription polymerase chain reaction
Vitamin B12 injections are very safe and well tolerated