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For the NHS, this is likely to mean a rebound in obesity rates over the next five years, driving costs back up and piling extra pressure onto a service thats already under strain

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When GI adverse effects remain severe or refractory despite these measures, temporary discontinuation of GLP-1 RA therapy or a structured drug holiday may be appropriate

Risk Summary A clinical lactation study reported semaglutide concentrations below the lower limit of quantification in human breast milk

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