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Numerous studies have shown that GSH anabolism and GPX4 are inextricably linked to ferroptosis

The GSH tripeptide (- L-glutamyl-L-cysteinyl-glycine), the most abundant water-soluble non-protein thiol in the cell (110 mM) is fundamental for life by (a) sustaining the adequate redox cell signaling needed to maintain physiologic levels of oxidative stress fundamental to control life processes, and (b) limiting excessive oxidative stress that causes cell and tissue damage

Dysregulated iron homeostasis has been linked to hyperphosphorylation and NFT development (42)

Pineapple: Contains bromelain, an enzyme that supports the action of glutathione in the body

10.1016/j.redox.2020.101494 6 AshrafA.StosnachH.ParkesH

Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I