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Increases in extracellular K + mediated by neuronal activities, along with vasoconstrictors such as endothelin 1 (ET1), PDGFB, and blood-derived insulin-like growth factor 1 (IGF1), trigger Ca 2+ entry into pericytes through VGCCs, causing depolarization and contraction [7, 93]

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58 Nagira et al observed that TSS inhibited the development of endometriotic lesions in surgically induced BALB/c mice

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Over time, the renewal dynamic changes: the balance between synthesis and degradation evolves, which can lead to visible changes (loss of elasticity, wrinkles) and functional changes (sensations of stiffness, variable joint comfort depending on activity)

Clinical studies have established a robust correlation between biological aging and AF incidence