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Impaired mitochondrial function in dopaminergic neurons in the substantia nigra can lead to increased oxidative stress, neuronal damage, and neuronal death, contributing to PD progression [20]
Linsitinib also restored the sensitivity of ovarian clear cell carcinoma (OCCC) cells to the chemotherapy drug cisplatin by silencing the IGF-1R/AKT signaling pathway (52)
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