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Weight loss itself changes hormone levels, which can alter menstrual patterns

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

The pattern typically unfolds over months: tirzepatide produces weight loss and inflammation reduction, which allows a gradual steroid taper, which further improves weight and metabolic health, which may allow additional steroid reduction

Patients experiencing severe side effects should report them immediately through the app and seek medical attention if symptoms are serious

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) drug

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