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To assess copper-dependent regulation of autophagy-related genes, the expression of six genes ( HSP90AA1 , GABARALP1 , UBC , PRAGC , PLOD2 , LAMTOR3 ) was measured in HepG2 and HepG2 ATP7B-KO cells after CuCl treatment

C., Mattison, J

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The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

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