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Bagel 2014

This may be explained by differences in body composition and should be taken into account when dosing or following factor VIII levels in the pediatric population.4 Because clearance (based on per kg body weight) has been demonstrated to be higher in the pediatric population, dose adjustment or more frequent dosing based on per kg body weight may be needed in this population [see Clinical Pharmacology (12.3)]

Absorption Needs : For those with digestive issues or concerns regarding absorption, liposomal glutathione might be the better option due to its superior bioavailability

Bridging this gap represents a critical translational challenge and an opportunity to refine both diagnostic and therapeutic strategies

"Cobalamin Deficiency: Clinical Picture and Radiological Findings"